ИСТИНА

The extracellular degradome of A. ochraceus VKM-F4104D consists of 58 peptidases. Among them, 32 are endopeptidases and 26 are exopeptidases. They were classified according to the MEROPS database as aspartic (11), cysteine (2), glutamic (2), serine (21), threonine (1), and metallopeptidases (21). These peptidases have different functions and participate in nutrition, pathogen–host interaction and invasion, pH regulation, microbial antagonism, cell death and autolysis, and regulation of cell physiology. Some of the enzymes arose due to horizontal gene transfer. The most abundant and expressed are deuterolysins, aspergillopepsins, subtilisins and carboxypeptidases (S10). Thus, understanding fungi’s degradomics, especially those tightly interacting with humans, is key to many biotechnological, pharmacological, and industrial solutions.