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The dermo-epidermal contact zone plays an important role in forming the skin protective barrier. It is known that age-related changes in permeability of the skin barrier play an important role in age-related skin changes. The objective of the present work is to study the ultra-structure of the zone of dermo-epidermal contact among the members of various age groups. Materials and methods. An electron-microscopy study of 32 skin bioptates from generally healthy individuals belonging to 5 age groups (from 6 month to 7 years, from 7 to 19 years, from 20 to 40 years, from 41 to 59 years, from 60 to 74 years and from 75 to 89 years of age) was conducted. Results. In the skin of children of under 7 years of age we discovered underdevelopment of the zone of dermo-epidermal contact: reduced number of anchoring fibers, irregular location of hemidesmosomes, weak development of the tonofilament system in epidermis. In age groups of 7 to 19 and 20 to 40 years of age we discovered a well-formed dermo-epidermal join. Changes in various skin structures start after 40 years of age and strengthen over time. The strongest changes in dermo-epidermal join are noted in the later period, that is among those between 60 and 74, and those between 75 and 89 years of age. These changes include the thinning and duplication of the basal membrane and a reduction in the number of hemidesmosomes. Conclusion. Age-related changes of the basal membrane suggest disturbance of its barrier function and the compensatory process, occurring in this zone.