ИСТИНА

Development of highly sensitive nano-biosensors for rapid detection and analysis of chemicals, biomolecules, and bio-objects is a crucial task in laser technology. A serious breakthrough in the field of biosensorics is now expected from the application of the optical non-invasive method of Surface-Enhanced Raman Scattering (SERS) for these purposes, as it is characterized by high sensitivity, specificity and rapid response. The SERS method consists in amplifying the intensity (in billions of times) of the optical Raman signal from the molecules of the analyzed substance using special SERS -active substrates containing noble metal particles (usually gold, silver, copper) to register the signal. The sensitivity of the method directly depends on the morphological features of the substrates used: not only the shape and size of metal particles, but also their location in the solid-state matrix - the base of the sensor layer - is of great importance.