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PHOSPHORUS (V) TETRAPYRROLIC COMPLEXES: FROM SYNTHESIS TO BIOMEDICAL APPLICATIONSдоклад на конференции
- Авторы: Safonova E.A., Polovkova M.A., Efimova I.A., Ovchenkova A.E., Gorshkov E.V., Akasov R.A., Gorbunova Yu G.
- Международная Конференция (Конгресс) : XXII Mendeleev Congress on General and Applied Chemistry, October 7-12, 2024, Federal Territory “Sirius”, Russia.
- Даты проведения конференции: 7-12 октября 2024
- Дата доклада: 9 октября 2024
- Тип доклада: Устный
- Докладчик: Safonova E.A.
- Место проведения: Sochi, Россия
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Аннотация доклада:
We have demonstrated that P(V) porphyrins and phthalocyanines are highly effective at generating singlet oxygen under light irradiation. P(V) porphyrins were found to exhibit high light-induced cytotoxicity (IC50=0.010) which is promising for photodynamic therapy (PDT). In contrast, P(V) phthalocyanines demonstrate relatively low dark and light cytotoxicity rendering the complexes unsuitable for PDT. Nevertheless, recently we have shown that they can be employed as photoinitiators for photocuring of bio-compatible polymers and subsequently for tissue engineering.
- Добавил в систему: Сафонова Евгения Александровна