ИСТИНА

Electrolyte-gated organic field-effect transistors (EGOFET) are widely used as a platform for biosensors, providing low analyte detection limits and high specificity. Antibodies, enzymes, proteins, and aptamers are used as recognition elements for biosensors based on EGOFET. Compared to antibodies and enzymes, aptamers are resistant to heat, pH changes and chemically aggressive conditions. Therefore, aptamers are more effective substances for practical use. The use of aptamers opens up a method for sensitive, selective and affordable detection of biomolecules. Furthermore, due to their unique structure, aptamers can be used to detect multiple analytes under different conditions. This property of aptamers was investigated in this work to determine the possibility of controlling the properties of biosensors based on EGOFET using an aptamer with i-motif structure.