ИСТИНА

Homogeneous Pd(0)-catalyzed amination reactions can be successfully applied to the synthesis of N-aryl and N-heteroaryl substituted linear polyamines, nitrogen-containing macrocycles, macropolycycles and biologically active derivatives of adamantane-containing amines. The application of much cheaper copper catalysis also allows (hetero)arylation of amines and polyamines. The selectivity of the copper-mediated reactions dramatically depends on the nature of (poly)amines and (hetore)aryl halides and on the composition of the catalytic system.