ИСТИНА

Ascomycete fungus Podospora anserina is frequently used as a model organism in studies on the mechanisms of ageing due to its limited lifespan with clear signs of senescence on solid media. However, it shows no evidence of senescence when cultured under aeration in liquid media. The mechanisms underlying the unlimited vegetative growth are unknown. We conducted a long-term submerged cultivation experiment of eight replicate lineages of P. anserina and analyzed genetic changes that arose and became fixed in these lineages during the cultivation. Several lines of evidence suggest that some of the acquired mutations might be adaptive.