ИСТИНА

Introduction: The participation of stress hormones and proteins in ontogenetic regulation is a theme of earlier and recent research (see our parallel presentation). However, the mechanisms underlying such participation are far from clear yet. Objective: The present work aimed at establishing the importance of redox control and oxidative stress in regulatory mechanisms involving stress hormones and proteins. Methodology: In order to localize the studies of interest, we performed bibliographic search utilizing the following key words: stress proteins, glucocorticoids, oxidative stress, redox regulation, ontogeny, and some others. Various databases, as well as Public Domain of Internet were explored using Scholar Google, preferably in English, during the last 45 years. Results: Literature data confirm that glucocorticoids can provoke oxidative stress in the body and target organs. Besides, the importance of various stress proteins in redox control is increasingly established. Conclusions: Since one of the theories of aging is based on oxidative damage to mitochondria and macromolecules, the role of stress hormones and proteins in pathogeny of age-related disorders becomes better justified. In this respect, the use of antioxidants like vitamins C and E, SkQ1, etc. for diminution of adverse effects of glucocorticoids and their contribution to programming / imprinting phenomena is a promising avenue of future investigations