ИСТИНА

Objective: The TP53 gene is a classic tumor-suppressor gene. The p53 protein from abnormal TP53 gene has a longer half-life, accumulates inside cells and is a marker of malignant transformation. Method: We assessed immunohistochemical expression of p53 in 28 hyperplastic polyps (HPs), 30 sessile serrated adenomas (SSAs), 15 traditional serrated adenomas (TSAs), 30 tubular adenomas (TAs) and 28 tubulovillous adenomas (TVAs). Results: The aberrant expression of p53 (>5% cells) was detected in 26.1% HPs, 30.0% SSAs, 33.3% TAs, 60.7% TVAs and 73.3% TSAs. In all HPs and SSAs p53 positive cells were located in lower part of the crypts; in TAs, TVAs and TSAs - in superficial half or throughout the crypts. Pattern of distribution was similar between HPs and SSAs, TSAs and TVAs, TVAs and TAs (p<0.05). Medium amount of p53 positive cells was 6.6% in HPs, 6.0% in SSAs, 10.5% in TAs, 26.5% in TVAs and 25.4% in TSAs. Conclusion: Summarized pattern of p53 expression are similar between TSAs and TVAs, HPs and SSAs (p<0.05). According to p53 expression levels TSAs and TVAs show the highest malignant potential, HPs and TSAs – the lowest, TAs show intermediate features. The reported study was funded by RFBR according to the research project №16-34-00179 mol_a.