ИСТИНА

Complicacy in the study of functional role of potassium channels and revealing an expression and activity levels of these channels in cells and tissue is related to restricted selectivity of known modulators or even to absence of highly selective ligands. That is why development of highly active and selective channel ligands is of exceptional importance. Our goal is the study of molecular basis for selectivity of interactions between peptide ligands and potassium channels, the development of principles and means for design of selective high-affinity potassium channel peptide blockers using molecular modeling.