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Efficient fold-change detection based on protein-protein interactionsдипломная работа (Бакалавр)
- Научный руководитель: Sheinman Michael
- Автор: W Buijsman
- Тип: Бакалавр
- Организация, в которой проходила защита: vrije universiteit amsterdam
- Год защиты: 2014
- Аннотация: Various biological sensory systems exhibit a response to a relative change of the stimulus, often referred to as fold-change detection. In the past few years, fold-change detecting mechanisms, based on transcriptional networks, have been proposed. Here we present a fold-change detecting mechanism, based on protein-protein interactions, consisting of two interacting proteins. This mechanism does not consume chemical energy and is not subject to transcriptional and translational noise, in contrast to previously proposed mechanisms. We show by analytical and numerical calculations that the mechanism is robust and can have a fast, precise, and efficient response for parameters that are relevant to eukaryotic cells.
- Добавил в систему: Sheinman Michael