ИСТИНА

Создание и описание новых коллоидных систем, в том числе биомиметических магниточувствительных нанокомпозитов на основе биосовместимых полимеров, перспективных как для направленной, так и для пассивной доставки лекарственных соединений непосредственно в целевую область организма для повышения эффективности их применения и понижения побочной токсичности препаратов для здоровых тканей.

Currently, one of the most urgent interdisciplinary problems at the junction of biophysics, chemistry and medicine is the creation of new effective drug therapy systems based on selective and targeted delivery of drugs directly to certain areas of the body that are the goals of therapeutic action. The solution to this problem is related to the development of biocompatible colloidal drug encapsulation agents capable of providing controlled targeted delivery and release of drugs to target areas of the body. At the same time, the localization of colloidal drug carriers in biological liquid media of the body can be controlled by chemical, biochemical and physical (in particular, magnetic) influences. The aim of the work is to create and describe new colloidal systems, including biomimetic magnetically sensitive nanocomposites based on biocompatible polymers, promising for both directed and passive delivery of medicinal compounds directly to the target area of the body to increase the effectiveness of their use and reduce the side toxicity of drugs for healthy tissues. During the implementation of the research project, it is planned to perform the following tasks: (1) Creation and characterization of colloidal systems for targeted delivery, including polymer complexes based on various biocompatible polymers. Also, during the implementation of the project, it is planned to study the possibility of using colloidal systems of a different nature for targeted delivery. (2) Creation of polycomplexes with magnetic properties. (3) Study of the interaction of polycomplexes with various membrane systems: biological and model (monolayer systems, bilayer lipid membranes). (4) Creation of a model and theoretical description of the interaction of polycomplexes functionalized by magnetic nanoparticles with external electromagnetic fields. (5) Exploring the possibility of controlled delivery using an external magnetic field. Development and staging of the experiment. The implementation of the project will make it possible to develop composite polycomplexes based on biocompatible polymers that are promising for biomedical applications, where a molecule with therapeutic activity is used as a structural component. In the future, the results of the work can be used to create an effective biomedical platform that provides targeted delivery and controlled release of biologically active substances, including drugs, in living systems. Also, the importance of the results obtained during the implementation of the project is due to the fact that they can form a scientific basis for solving the fundamental scientific problem of biomedical radioelectronics, consisting in the development of new effective therapeutic strategies for targeted controlled delivery of drugs to target areas of the human and animal body, which is necessary for breakthrough development and cardinal improvement of the effectiveness of means and methods of therapy.- significant diseases. At this stage, the possibility of creating polymer complexes based on biocompatible molecules of sodium polyacrylate and biogenic polyamine spermine was studied. The main physico-chemical characteristics of polymer complexes have been partially determined, and the possibility of including the medicinal antitumor drug doxorubicin in polycomplexes has been demonstrated. The possibility of functionalization of polycomplexes by magnetic nanoparticles is shown. The applicant has experience working with colloidal systems for the delivery of medicinal compounds on the basis of the Faculty of Physics of Moscow State University, Skoltech, the Department of Navy of the Faculty of Chemistry and the V. A. Kotelnikov Institute of Radio Engineering and Electronics of the Russian Academy of Sciences.