Preparation and characteristics of Ca2+-dependent monoclonal antibodies to recoverinстатья
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Дата последнего поиска статьи во внешних источниках: 16 июня 2015 г.
Аннотация:Thirty-four primary hybridoma clones were prepared which expressed monoclonal antibodies to the Ca2+-binding protein recoverin. Among the resulting monoclonal antibodies, two Ca2+ -dependent clones (mAb3 and mAb19) recognizing recoverin were detected by solid-phase immunoenzyme assay In the presence of Ca2+, antibodies of the mAb3 and mAb19 clones bound to recoverin several times better than in the absence of Ca2+. The mAb3 and mAb19 antibodies recognized epitopes located inside the sequences Pro61-Met91 and Pro57-Tyr64 of the recoverin molecule, respectively The possible mechanism of the Ca2+-dependent recognition of recoverin by the prepared monoclonal antibodies is discussed.