|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
The Effect of Molecular Architecture of Sulfobutyl Ether β-Cyclodextrin Nanoparticles on Physicochemical Properties of Complexes with Moxifloxacinстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.
- Авторы: Skudredina A.A., Le-Deigen I.M., Kudryashova E.V.
- Журнал: Colloid Journal
- Том: 80
- Номер: 3
- Год издания: 2018
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 312
- Последняя страница: 319
- DOI: 10.1134/S1061933X18030134
- Аннотация: A procedure has been developed for preparing nanoparticles from oligomers of sulfobutyl ether β- cyclodextrin (SBE-β-CD) and their structure has been studied by FTIR spectroscopy. The physicochemical properties of “guest−host” inclusion complexes formed by SBE-β-CD and its oligomers with moxifloxacin have been investigated. It has been shown that, as compared with SBE-β-CD, the synthesized oligomers have an increased affinity for moxifloxacin: the dissociation constants for the complexes of monomeric and oligomeric SBE-β-CD are (1.0 ± 0.3) × 10−4 and nearly 5 × 10−6 M, respectively. The binding efficiency increases due to the many-point interaction of a moxifloxacin molecule with functional groups of the oligomeric carrier. SBE-β-CD oligomers are promising carriers for drugs, in particular, fluoroquinolone-based antibacterial agents, and may be used for the development of new compositions with improved solubility, bioavailability, and prolonged drug release.
- Добавил в систему: Скуредина Анна Алексеевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | CollJour1803013SkuredinaKOR.pdf | 686,7 КБ | 26 марта 2018 [anna.skuredina] |