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Working memory and N-acetylaspartate level in hippocampus, parietal cortex and subventricular zoneстатья Тезисы
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Kozlovskiy S., Vartanov A., Pyasik M., Polikanova I.
- Журнал: International Journal of Psychology
- Том: 47
- Год издания: 2012
- Издательство: Psychology Press
- Местоположение издательства: United Kingdom
- Первая страница: 584
- Последняя страница: 584
- DOI: 10.1080/00207594.2012.709117
- Аннотация: Introduction. Recent studies show that decreased N-acetylaspartate (NAA) level results in memory decline in animals (Xi, 2011) and in humans with mental disorders (Bertolino, 2003; Harris, 2006). In present study we compared memory tests performance and NAA level in different brain structures of healthy subjects. Methods. Subjects: 18 right-handed females (mean age – 59±16) without neurological and mental disorders. All subjects performed working memory tests – verbal and spatial N-back task and visual memory task of complex spatial figures (“snake”). NAA levels in hippocampus, inferior parietal cortex and subventricular zone of both hemispheres were measured with proton magnetic resonance spectroscopy performed with 3T MRI scanner. The received data was analyzed by calculating non-parametric correlations (Spearman, p < 0.05) between individual behavioral and biochemical measurements. Results and conclusions. According to the obtained data, N-back task performance correlates negatively with NAA level in right hippocampus. Moreover, the amount of correct answers in verbal task variation correlates positively (0.71), whereas in spatial task variation the correlation is negative (-0.81). “Snake” test performance correlates positively with NAA level in left hippocampus (0.83). Reaction time in both variations of N-back task correlates negatively (-0.83 for verbal and -0.70 for spatial variations) with NAA level in subventricular zone. No significant correlations between memory tests performance and NAA level in inferior parietal cortex were revealed. Thus, NAA level in both hippocampi and subventricular zone might indicate working memory functioning characteristics in healthy humans.
- Добавил в систему: Вартанов Александр Валентинович