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HIV-1 genetic diversity in recently diagnosed infections in Moscow: predominance of AFSU, frequent branching in clusters, and circulation of the Iberian subtype G variantстатья
- Авторы: Karamov E., Epremyan K., Siniavin A., Zhernov Y., Cuevas M.T., Delgado E., Sanchez-Martinez M., Carrera C., Kornilaeva G., Turgiev A., Bacque J., Perez-Alvarez L., Thomson M.M.
- Журнал: AIDS Research and Human Retroviruses
- Год издания: 2018
- Издательство: Mary Ann Liebert Inc.
- Местоположение издательства: United States
- DOI: 10.1089/AID.2018.0055
- Аннотация: HIV-1 protease-reverse transcriptase sequences from 62 HIV-1-infected individuals recently diagnosed in Moscow were analyzed. Subtype A former Soviet Union (FSU) (AFSU) variant was the predominant clade (62.9%), followed by subtype B (22.6%), unique recombinants (6.5%), subtype G (6.5%), and CRF01_AE (1.6%). AFSU predominated among people who inject drugs (88.9%) and heterosexually-acquired infections (77.8%), while subtype B was the most prevalent genetic form among men who have sex with men (44%), although AFSU was also frequent in this population (36%). Forty eight (77.4%) viruses branched within intrasubtype clusters, three of which, of subtype B, had a majority of viruses collected outside of FSU. The four subtype G viruses identified in this study belonged to the Portuguese-Spanish (Iberian) variant and, together with three from data bases, formed a Russian cluster closely related to viruses from Denmark. This is the first report of the circulation of the Iberian subtype G variant in Russia.
- Добавил в систему: Жернов Юрий Владимирович