Planar-chiral rhodium(III) catalyst with sterically demanding cyclopentadienyl ligand and its application for enantioselective synthesis of dihydroisoquinolonesстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 2 октября 2018 г.
Аннотация:Rapid development of enantioselective CH‐activation reactions created a demand for new types of catalysts. Herein we report the synthesis of a novel planar‐chiral rhodium catalyst [(C5H2tBu2CH2tBu)RhI2]2 in two steps from commercially available [(cod)RhCl]2 and tert‐butyl acetylene. Pure enantiomers of the catalyst were obtained through separation of its diastereomeric adducts with natural proline. The catalyst promoted the enantioselective reaction of arylhydroxamic acids with strained alkenes giving dihydroisoquinolones in high yields (up to 97%) and with good stereoselectivity (up to 95% ee).