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Role of Mechanics in Rhythm Disturbances in 1D Mathematical Model of Myocardial Tissue with Local Ca2+-Overload cardiomyocytesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Дата последнего поиска статьи во внешних источниках: 17 апреля 2018 г.
- Авторы: Kursanov A., Solovyova O., Katsnelson L., Markhasin V.S.
- Журнал: Computing in cardiology
- Том: 42
- Год издания: 2015
- Издательство: Computing in Cardiology
- Местоположение издательства: [S.l.],
- Первая страница: 549
- Последняя страница: 552
- DOI: 10.1109/CIC.2015.7410969
- Аннотация: Possible contribution of the mechanics to the arrhythmogenesis in Ca2+ overloaded cardiomyocytes has been under appreciated. Earlier developed mathematical model of cardiomyocyte electromechanical function predicted a significant role of intra- and extracellular mechanical factors in triggering rhythm abnormalities. We utilized the cellular model to study effects of the electromechanical coupling between cardiomyocytes in a 1D heterogeneous muscle strand comprised normal (N) and sub-critical (SC) cardiomyocytes with moderately decreased Na+-K+ pump activity. The single SC cardiomyocytes did not demonstrate spontaneous activity during isometric contractions at a reference length. In the tissue, excitation spreads via electro-diffusional cell coupling and activates cell contractions and force development. Mechanical interactions between Nand SC-cells in the tissue resulted in the spontaneous activity emerged in the SC zone between the regular stimuli. The results suggest that ectopic activity may emerge in a rather small SC-region and expand by capturing normal regions in myocardium due to the electromechanical coupling between cardiomyocytes.
- Добавил в систему: Курсанов Александр Геннадьевич