Selective N1-Alkylation of 1,3-Dibenzoyluracils: One-Pot Way to N1-Monosubstituted Uracil DerivativesстатьяИсследовательская статья
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Дата последнего поиска статьи во внешних источниках: 17 апреля 2018 г.
Аннотация:A new method for synthesis of N¹-monosubstituted uracils and 5- and 6-methyluracil derivatives was developed. It consists in the selective N¹-deprotection of N¹,N³-dibenzoyluracils in anhydrous dimethylformamide in the presence of potassium carbonate at room temperature and subsequent N¹-alkylation by allyl, benzyl or phenacyl type halides or by primary alcohols toluenesulfonates conducted one-pot without isolation of the intermediates. Final N³-debenzoylation by aqueous-alcoholic solution of ammonia affords the corresponding N¹-monosubstituted uracil derivatives with overall yields of 52-84%.