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Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent mannerстатья Исследовательская статья Электронная публикация
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.
- Авторы: Lee Byung Cheon, Lee Hae Min, Kim Sorah, Avanesov Andrei S., Lee Aro, Chun Bok-Hwan, Vorbruggen Gerd, Gladyshev Vadim N.
- Журнал: Scientific reports
- Том: 8
- Номер: 1
- Год издания: 2018
- Издательство: Nature Publishing Group
- Местоположение издательства: United Kingdom
- Первая страница: 1
- Последняя страница: 11
- DOI: 10.1038/s41598-017-15090-5
- Аннотация: Accumulation of oxidized amino acids, including methionine, has been implicated in aging. The ability to reduce one of the products of methionine oxidation, free methionine-R-sulfoxide (Met-R-SO), is widespread in microorganisms, but during evolution this function, conferred by the enzyme fRMsr, was lost in metazoa. We examined whether restoration of the fRMsr function in an animal can alleviate the consequences of methionine oxidation. Ectopic expression of yeast fRMsr supported the ability of Drosophila to catalyze free Met-R-SO reduction without affecting fecundity, food consumption, and response to starvation. fRMsr expression also increased resistance to oxidative stress. Moreover, it extended lifespan of flies in a methionine-dependent manner. Thus, expression of an oxidoreductase lost during evolution can enhance metabolic and redox functions and lead to an increase in lifespan in an animal model. More broadly, our study exposes the potential of a combination of genetic and nutritional strategies in lifespan control.
- Добавил в систему: Гладышев Вадим Николаевич