Nanoparticle-based paper sensor for thiols evaluation in human skinстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.
Аннотация:A new sensitive non-invasive gold nanoparticle-based sensor that enables to detect thiols in
the human skin has been developed. The detection procedure implied the assessment of the color
change of a paper sensor resulting from aggregation of gold nanoparticles caused by thiols. The
ratio of the intensity of the photo image blue channel vs the red one (in units of RGB coloration)
served as analytical response. The main thiol in the skin is glutathione, therefore, it was used as
model biothiol and spiking substance. The range of linearity for glutathione was 8 - 75 µM, the
detection limit - 6.9 µM. RSD≤7% is for inter-day determination of 10 μM glutathione and
RSD≤12% is the intra-day value. The recovery of 5 µM and 10 µM of glutathione was evaluated
by applying solution, containing thiol-spikes, on skin. The results varied in the range 77 - 138 %.
A hundred-fold excess of serine, alanine, histidine, threonine, creatinine, urea, and ammonia; a
ten-fold excess of glycine, proline, leucine, isoleucine, phenylalanine, asparagine; and a five-fold
excess of valine, tryptophan, tyrosine, and uric acid, which can be extracted from the skin and is
contained in the test matrix, have no significant effect on 10 µM glutathione signal. Thiols level
in the skin of volunteers (21-65 years old, men and women) detected with the use of a proposed
non-invasive sensor was 11.6 – 47.5 µM.