Аннотация:Методом акустоплазменного разряда были получены наночастицы оксидов различных металлов.
Проведенные исследования полученных наночастиц в экспериментах in vitro на различных клеточных линиях не выявили их цитоксичности вплоть до концентраций 0,2 мг/мл и времени экспозиции 7 дней, что указывает на хорошие перспективы их биомедицинских применений в качестве средств диагностики и магнитной гипертермии.
INVESTIGATION OF THE PHYSICAL PROPERTIES AND CYTOTOXICITY OF NANOPARTICLES OF METAL OXIDES OBTAINED BY THE DISCHARGE AT ULTRASONIC CAVITATION
V.N. Nikiforov, N.A. Bulychev, M.A. Kazaryan, V.V. Pryadun, S.N. Shevchenko, V.G. Yakunin, V.Yu. Timoshenko, A.B. Bychenko, A.V. Ivanov
By using acoustic-plasma method were synthesized nanoparticles of various oxides of metals – tungsten, copper, iron, zinc, – and demonstrated that the presence of ultrasonic cavitation in the synthesis of the nanoparticles significantly affects their dimensions and physical characteristics. The sizes of nanoparticles were determined by electron microscopy and laser correlation spectroscopy, the results of which were in good agreement. For example a distinction tungsten oxide nanoparticles photoluminescence spectrum obtained in the absence and in the presence of ultrasonic cavitation. Studies nanoparticles obtained in experiments in vitro on various model cell lines did not reveal their cytotoxicity up to the concentration of 0.2 mg/ml and exposure time of 7 days, which indicates good prospects for biomedical applications as a means of diagnosis and magnetic hyperthermia.
Key words: nanoparticles, metal oxides, plasma, ultrasound, cavitation, citotoxicity