Leishmania donovani: Structural insignt in the recognition of C-methylated analogues of spermidine as natural polyaminesстатья
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Дата последнего поиска статьи во внешних источниках: 11 декабря 2015 г.
Аннотация:The ability of alpha-, nu-, gamma- and omega-methylated spermidine analogues to restore the growth of L. donovani promastigotes that were depleted of putrescine and spermidine was investigated. Only beta-methylated spermidine, like natural spermidine, was capable of restoring the growth of L. donovani, while the remaining three analogues turned out to be inactive. alpha-Methylated spermidine is a functionally active spermidine surrogate both in vivo and in vitro, hence this analogue may be considered as an antidote in the host-parasite system, especially in the cases where inhibitors of polyamine biosynthesis are used for the therapy of leishmaniasis.