Laccase Cat calyzed Heterocoupling of Dihydroquercetin and p-Aminobenzoic Acid: Effect of the Reaction Product on Cultured Cellsстатья
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Дата последнего поиска статьи во внешних источниках: 2 октября 2018 г.
Аннотация:Derivatization of the natural flavonoid dihydroquercetin with para-aminobenzoic acid was carried out in an ethyl acetate/citric buffer biphasic system using laccase from the fungus Trametes hirsuta. The main reaction product yield was ~68 mol%. The product was characterized by 1H NMR, 13C NMR, and liquid chromatography, mass spectroscopy, and its structure was elucidated. The reaction product affected viability of cultured human rhabdomyosarcoma cells (RD cell line)in a dose-dependent manner and, therefore, can be of interest to pharmaceutical industry.