Hydrolytic Degradation of Poly(3-hydroxybutyrate) and Its Copolymer with 3-hydroxyvalerate of Different Molecular Weights in vitro

Zhuikov, V.А.; Bonartsev, А.P.; Makhina, Т.К.; Myshkina, V.L.; Voinova, V.V.; Bonartseva, G.А.; Shaitan, K.V.

Авторы: Zhuikov V.А., Bonartsev А.P., Makhina Т.К., Myshkina V.L., Voinova V.V., Bonartseva G.А., Shaitan K.V.
Журнал: Biophysics
Том: 63
Номер: 2
Год издания: 2018
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 169
Последняя страница: 176
DOI: 10.1134/S0006350918020288
Аннотация: Английский вариант статьи Жуйков В.А с соавт. Биофизика, 2018, 63(2), 249-257. The hydrolytic degradation of polymer films of poly(3-hydroxybutyrate) of different molecular weights and its copolymers with 3-hydroxyvalerate (9 mol % 3-hydroxyvalerate in the poly(3-hydroxybutyrate) chain) of different molecular weights was studied in model conditions in vitro. The changes in the physicochemical properties of the polymers were investigated using different analytical techniques: viscometry, differential scanning calorimetry, gravimetrical method, and water contact angle measurement for polymers. The data showed that in a period of 6 months the weight of polymer films decreased insignificantly. The molecular weight of the samples was reduced significantly; the largest decline (up to 80% of the initial molecular weight of the polymer) was observed in the high-molecular-weight poly(3-hydroxybutyrate). The surface of all investigated polymers became more hydrophilic. In this work, we focus on a mathematical model that can be used for the analysis of the kinetics of hydrolytic degradation of poly(3-hydroxyaklannoate)s by noncatalytic and autocatalytic hydrolysis mechanisms. It was also shown that the degree of crystallinity of some polymers changes differently during degradation in vitro. Thus, the studied polymers can be used to develop biodegradable medical devices such that they can perform their functions for a long period of time.
Добавил в систему: Бонарцев Антон Павлович

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Hydrolytic Degradation of Poly(3-hydroxybutyrate) and Its Copolymer with 3-hydroxyvalerate of Different Molecular Weights in vitroстатья Исследовательская статья

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