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Executive Functions in Naive Middle-age Patients with Uncomplicated Essential Arterial Hypertensionстатья Тезисы
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 22 февраля 2019 г.
- Авторы: Pervichko E., Ostroumova T., Darevskaya M., Borisova E., Korsakova N., Nikonova E., Kovtoniuk S., Ostroumova O.
- Журнал: International Journal of Psychophysiology
- Том: 131
- Номер: 10
- Год издания: 2018
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 92
- DOI: 10.1016/j.ijpsycho.2018.07.258
- Аннотация: IntroductionIt has been shown that persons diagnosed with EAH in middle age, are characterized by a rapid rate of annual decline in executive functions [Debette, 2011].The purpose of this study was to assess cognitive functions in EAH patients and, on this basis, to evaluate executive functions of the patients.MethodsResearch design, analysis and data interpretation were carried out in accordance with fundamentals of L.S. Vygotsky’s concept of mental development, and Vygotsky-Luria-Zeigarnik concept of psychological syndrome analysis. Psychological study was focused on the assessment of qualitative features of cognitive functions: the ability to keep the focus and follow a single strategy in problem solving, to control the process, to suggest the most appropriate solutions for generalizations in the course of the experiment.The following methods were used: Trail Making test (TMT), MoCA test, Verbal fluency test, Stroop test, CERAD 10-word list, and Pictogram test.The study involved 56 naive middle-age patients with uncomplicated EАH, stage 1-2, average age is 50,4±7,4, and 58 normotensive persons, average age is 46,0±4,7.ResultsEAH patients significantly differ from healthy subjects by the following parameters: TMT (B) (117,7±23,9 vs 102,0±26,7; p=0,01); TMT (B) – TMT (A) (81,7±41,2 vs 61,4±24,4; p=0,006); MoCA (28,17±1,7 vs 29.06±1,1; p=0,03); Stroop 3 (126,2±44,2 vs 114,5±27,5; p=0,002), and Stroop coefficient (60,6±37,4 vs 49,6±21,8; p=0,001).Pictogram test has revealed the predominance of concrete images over symbolically generalized for EAH patients (1,9±1,4 vs 0,9±0,9; p=0,04); decreasing quantity of the accurately recalled words (6,8±2,6 vs 9,4±3,3; p=0,000); essential quantity of not recalled words (5,5±2,8 vs 2,8±2,4; p=0,000); decreasing quantity of the recalled of affectively saturated words (4,9±2,5vs 2,7±2,5; p=0,000), and anxiety markers in pictograms (5,6±4,5 vs 2,8±3,5; p=0,000).The analysis of the results obtained using the principles of neuropsychological syndrome analysis (Luria school) leads us to the conclusion, that 53% of EAH patients would display disturbances in programming, regulation, and control of mental activity. This manifests itself in disturbances of strategic decision making in problem solving, and in the impulsive character of most answers. These data bring forward the evidence of dysfunction of frontal lobes, according to the interpretation in the framework of neuropsychological syndrome analysis. The pathopsychological interpretation of the data may suggest a hypothesis of motivational background for described disturbances.ConclusionЕhe results obtained confirm the hypothesis about violations of executive functions in naive middle-age patients with uncomplicated EAH.The research was supported by RFBR; project № 17-06-00954.
- Добавил в систему: Первичко Елена Ивановна