Synthesis and properties of covalently closed DNA duplexes containing pyrophosphate and substituted pyrophosphate internucleotide groupsстатья
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Дата последнего поиска статьи во внешних источниках: 25 июля 2019 г.
Аннотация:A new method for the efficient synthesis of covalently closed DNA duplexes (DNA dumbbells) and the introduction of pyrophosphate and substituted pyrophosphate internucleotide groups into their structure is proposed. The method is based on chemical ligation in DNA duplexes that are formed by a polynucleotide the ends of which are brought together due to the introduction of the minihairpin structure