Synthesis of oligodeoxyribonucleotides containing oleylamine moietiesстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:A method for directional introduction of oleylamine residues to any position of oligodeoxyribonucleotides during their automated synthesis was developed. The presence of oleylamine residues in 3'- or 5'-terminal nucleotides was shown to have no effect on the thermodynamic stability of DNA duplexes formed by such oligonucleotides and the complementary sequences. The rate of hydrolysis of oligonucleotides containing oleylamine residues in the 3'-terminal units by the snake venom phosphodiesterase was shown to be markedly lower than that of natural oligonucleotides.