2′-aldehyde oligonucleotides: Synthesis and use for affinity modification of DNA-recognizing proteinsстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:Oligonucleotides with 1,2-diol group were prepared from 2′-O-[2-(2,3-dihydroxypropyl)amino-2-oxoethyl]uridine 3′-phosphoramidite. The thermal stability of modified DNA duplexes and their ability to form complexes with the p50 subunit of the NF-ϰB transcription factor and (cytosine-5)-DNA methyltransferase M.SsoII were studied. The periodate oxidation of the 1,2-diol group of the oligonucleotides resulted in reactive 2′-aldehyde derivatives. The opportunity of their use for the affinity modification of DNA-recognizing proteins was studied.