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Methyl-substituted trans-1,2-cyclohexanediamines as new ligands for oxaliplatin-type complexesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Habala L., Dworak C., Nazarov A.A., Hartinger C.G., Abramkin S.A., Arion V.B., Lindner W., Galanski M., Keppler B.K.
- Журнал: Tetrahedron
- Том: 64
- Номер: 1
- Год издания: 2008
- Издательство: Pergamon Press Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 137
- Последняя страница: 146
- DOI: 10.1016/j.tet.2007.10.069
- Аннотация: Three different pathways for the synthesis of substituted trans-(±)-1,2-cyclohexanediamines as new ligands for oxaliplatin-type compounds are presented. The different synthetic routes lead (i) by the synthesis of the compound via ortho-bromination of a substituted cyclohexanone followed by reaction with hydroxylamine and reduction by hydrogen, (ii) by addition of azide to cyclohexene mediated by manganese(III) acetate and reduction by hydrogen, or (iii) by trans-dihydroxylation of cyclohexene, and subsequent conversion into the respective mesylate or tosylate, followed by substitution by azide, and reduction in the case of 4-methyl-trans-(±)-1,2-cyclohexanediamine to a preferentially equatorially, mainly axially, or exclusively equatorially or axially oriented 4-methyl group, respectively. © 2007 Elsevier Ltd. All rights reserved.
- Добавил в систему: Назаров Алексей Анатольевич