Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moietiesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:The synthesis of conformationally restricted serotonin analogues based on indol derivatives annelated with bicyclo[3.3.1]nonane and bicyclo[3.2.1]octane moieties is described. The configuration of the amino group in a structure is proved on the basis of X-ray data for N-[(9R)-2-methoxy-6,7,8,9,10,11-hexahydro-5H-6,10-methanocycloocta[b]indol-9-yl]acetamide. The ex vivo testing results of four products to 5HT(3) serotonin receptors are presented.