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Effect of chronic fluoxetine treatment on audiogenic epilepsy, symptoms of anxiety and depression in rats of four linesстатья Исследовательская статья
Дата последнего поиска статьи во внешних источниках: 11 апреля 2019 г.
- Авторы: Sarkissova K.Y., Fedotova I.B., Surina N.M., Nikolaev G.M., Perepelkina O.V., Poletaeva I.I.
- Журнал: Doklady Biological Sciences
- Том: 4671
- Номер: 1
- Год издания: 2016
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 55
- Последняя страница: 58
- Аннотация: Anxiety (Anx) and depression (Dp) levels were evaluated in rats of 4 lines: 2 of them (KM and “4”) exhibited audiogenic seizures (AS), and 2 (Wistar and “0”) had no AS. In KM rats (with AS), Anx and Dp levels were higher than in Wistars (without AS), while in “4” and “0” rats with the related genetic background but contrasting in AS severity, Anx and Dp indices were not different. Fluoxetine treatment exerted antidepressant effect in all rat lines irrespective of its effect on AS. Thus, phenotypic expression of AS is not directly associated with the mechanisms of Anx and Dp development.
- Добавил в систему: Федотова Ирина Борисовна