Аннотация:Lysine dendrimers consist of natural lysine amino acid residues. Due to this reason,
they are usually not as toxic as other dendrimers.Lysine dendrimers are often used in
drug and gene delivery. These dendrimers penetrate blood-brain barrier and thus could
be used for the delivery of drugs and other substances, for example, bioactive peptides
to brain or elimination of disease-related peptides out of the brain. To do it, dendrimers
should form complex with these peptides. In the present chapter, we describe computer
simulation of the interaction of lysine dendrimer of the second generation with three
different peptides and check does it form complexes with them. Two of these peptides
(Semax and Epithalon) are nootropic peptides and third is the fragment of amyloid
peptide, which forms amyloid fibrils and plaques in Alzheimer’s disease. Our simula-tion demonstrates that the lysine dendrimers form complexes with these therapeutics
peptides. Thus, we demonstrated that lysine dendrimer is a good candidate for the
delivery of therapeutic peptides. We also have shown that lysine dendrimer destroys
existing stacks of amyloid peptides and forms a stable complex with them. Thus, it looks that it could be used in future for the treatment of Alzheimer’s diseases.
Keywords:lysine dendrimer, peptide delivery system, molecular dynamics, Semax,
Epithalon