Аннотация:The present study employed the method of mathematical statistics to investigate the relationship between the level of hypoglycemic activity and basic chemical structures of cyclic guanidine derivatives. A class of N 9-substituted 2,3-dihydro-imidazo[1,2-a] benzimidazole as the most likely to produce compounds with high hypoglycemic activity was identified by the method of supremum estimation.