Аннотация:Iron oxide nanoparticle/polymer microcapsules containing different number of layers of iron oxide nanoparticles have been made using the layer-by-layer alternating absorption technique. Nanoparticles as well as composite microcapsules have been characterized by TEM and SEM. The electronic paramagnetic resonance (EPR) spectra of water suspensions of iron oxide nanoparticles and microcapsules with iron oxide nanoparticles inside the capsule shell have been measured. Parameters of the EPR spectra are sensitivity to nanoparticle concentration in solution as well as to thermal and microwave microcapsules treatment. The shell permeability, as explored by confocal fluorescence microscopy, is decreased after temperature treatment of microcapsules but increased after microwave radiation. These results can find practical application in medicine and bioengineering for remote control over the permeability of microcapsule shells.