Sequencing and genetic characterization of two strains Paramushir virus obtained from the Tyuleniy Island in the Okhotsk Sea (2015)

Safonova, M.V.; Shchelkanov, M.Y.; Khafizov, K.; Matsvay, A.D.; Ayginin, A.A.; Dolgova, A.S.; Shchelkanov, E.M.; Pimkina, E.V.; Speranskaya, A.S.; Galkina, I.V.; Dedkov, V.G.

Авторы: Safonova Marina V., Shchelkanov Mikhail Yu, Khafizov Kamil, Matsvay Alina D., Ayginin Andrey A., Dolgova Anna S., Shchelkanov Egor M., Pimkina Ekaterina V., Speranskaya Anna S., Galkina Irina V., Dedkov Vladimir G.
Журнал: Ticks and Tick-borne Diseases
Год издания: 2018
Издательство: Elsevier BV
Местоположение издательства: Netherlands
DOI: 10.1016/j.ttbdis.2018.11.004
Аннотация: Paramushir virus belongs to Sakhalin virus genogroup within Orthonairovirus genus and is one of the poorly studied viruses with unknown pathogenicity. At the moment, only one nearly complete sequence of Paramushir virus genome, isolated in 1972, is available. Two new strains of PARV were isolated in 2015 from a sample collected at the Tyuleniy Island in the Okhotsk Sea and sequenced using a combination of high throughput sequencing and specific multiplex PCR. Both strains are closely related to the early sequenced PARV strain LEIV–1149 K. The signs of intersegment reassortment and probable recombination were revealed, which point to a high variability potential of Paramushir virus and may lead to the formation of strains with novel properties, different from those of the predecessors. The new data regarding Paramushir virus can promote a better understanding of the diversity and relations within Orthonairovirus genus and help define intragenic demarcation criteria, which have not yet been established.
Добавил в систему: Сперанская Анна Сергеевна

	ИСТИНА	Войти в систему Регистрация
	ИПМех РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИПМех РАН

Sequencing and genetic characterization of two strains Paramushir virus obtained from the Tyuleniy Island in the Okhotsk Sea (2015)статья

Прикрепленные файлы