Intracellular Cholesterol Deposition is Strictly Related to Mitochondrial Function: the Evidence from Studies in Cytoplasmic Hybridsстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 13 ноября 2019 г.
Аннотация:Since the nuclear background of different cybrid lines is kept
constant, this technique allowed to study the in
fluence of mtDNA mutation load on cell function. Cybrid cells differing only by the content of mitochondria and mtDNA from different donors are capable of accumulating
cholesterol to varying degrees when incubated with atherogenic LDL, that
is, they differ significantly by this indicator of functional activity.