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Antitumor Activity of Auger Electron Emitter 111In Delivered by Modular Nanotransporter for Treatment of Bladder Cancer With EGFR Overexpressionстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 16 января 2019 г.
- Авторы: Rosenkranz Andrey A., Slastnikova Tatiana A., Karmakova Tatiana A., Vorontsova Maria S., Morozova Natalia B., Petriev Vasiliy M., Abrosimov Alexey S., Khramtsov Yuri V., Lupanova Tatiana N., Ulasov Alexey V., Yakubovskaya Raisa I., Georgiev Georgii P., Sobolev Alexander S.
- Журнал: Frontiers in pharmacology
- Том: 9
- Номер: 1331
- Год издания: 2018
- Издательство: Frontiers Media]
- Местоположение издательства: [Lausanne, Switzerland
- Первая страница: 1
- Последняя страница: 14
- DOI: 10.3389/fphar.2018.01331
- Аннотация: Gamma-ray emitting 111In, which is extensively used for imaging, is also a source of short-range Auger electrons (AE). While exhibiting negligible effect outside cells, these AE become highly toxic near DNA within the cell nucleus. Therefore, these radionuclides can be used as a therapeutic anticancer agent if delivered precisely into the nuclei of tumor target cells. Modular nanotransporters (MNTs) designed to provide receptor- targeted delivery of short-range therapeutic cargoes into the nuclei of target cells are perspective candidates for specific intracellular delivery of AE emitters. The objective of this study was to evaluate the in vitro and in vivo efficacy of 111In attached MNTs to kill human bladder cancer cells overexpressing epidermal growth factor receptor (EGFR). The cytotoxicity of 111In delivered by the EGFR-targeted MNT (111In-MNT) was greatly enhanced on EJ-, HT-1376-, and 5637-expressing EGFR bladder cancer cell lines compared with 111In non-targeted control. In vivo microSPECT/CT imaging and antitumor efficacy studies revealed prolonged intratumoral retention of 111In-MNT with t1/2 = 4.1 ± 0.5 days as well as significant dose-dependent tumor growth delay (up to 90% growth inhibition) after local infusion of 111In-MNT in EJ xenograft-bearing mice.
- Добавил в систему: Соболев Александр Сергеевич