|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
QSAR for boiling points of "small" sulfides. Are the "high-quality structure-property-activity regressions" the real high quality QSAR models?статья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Zefirov N.S., Palyulin V.A.
- Журнал: Journal of Chemical Information and Modeling
- Том: 41
- Номер: 4
- Год издания: 2001
- Издательство: American Chemical Society
- Местоположение издательства: United States
- Первая страница: 1022
- Последняя страница: 1027
- DOI: 10.1021/ci0001637
- Аннотация: Our investigation was motivated by a recent paper concerning "high-quality structure-property-activity regressions" (J. Chem. Inf. Comput. Sci. 2000, 40, 899-905) for boiling points of small sulfides using variable connectivity indices. We performed QSAR study of the same data set using a logically preselected solvation index and obtained a very good one-parameter regression. The structures of the whole possible set of small sulfides (C2-C6) were generated and the statistics were proven by real prediction using an external test set of sulfides. The variants of extended prediction with extrapolated data and QSAR using an expanded training set were also performed, and all these data also revealed the preference of the solvation index. A general problem of descriptive vs predictive QSAR is discussed.
- Добавил в систему: Зефиров Николай Серафимович