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Comparative analysis of genome maintenance genes in naked mole rat, mouse, and humanстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 6 декабря 2018 г.
- Авторы: MacRae Sheila L., Zhang Quanwei, Lemetre Christophe, Seim Inge, Calder Robert B., Hoeijmakers Jan, Suh Yousin, Gladyshev Vadim N., Seluanov Andrei, Gorbunova Vera, Vijg Jan, Zhang Zhengdong D.
- Журнал: Aging Cell
- Том: 14
- Номер: 2
- Год издания: 2015
- Издательство: Blackwell Publishing Inc.
- Местоположение издательства: United Kingdom
- Первая страница: 288
- Последняя страница: 291
- DOI: 10.1111/acel.12314
- Аннотация: Genome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM‐associated genes in the naked mole rat (NMR), mouse, and human genomes. GM genes appeared to be strongly conserved, with copy number variation in only four genes. Interestingly, we found NMR to have a higher copy number of CEBPG, a regulator of DNA repair, and TINF2, a protector of telomere integrity. NMR, as well as human, was also found to have a lower rate of germline nucleotide substitution than the mouse. Together, the data suggest that the long‐lived NMR, as well as human, has more robust GM than mouse and identifies new targets for the analysis of the exceptional longevity of the NMR.
- Добавил в систему: Гладышев Вадим Николаевич