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Upregulation of NETO2 gene in colorectal cancerстатья
- Авторы: Fedorova Maria S., Snezhkina Anastasiya V., Pudova Elena A., Abramov Ivan S., Lipatova Anastasiya V., Kharitonov Sergey L., Sadritdinova Asiya F., Nyushko Kirill M., Klimina Kseniya M., Belyakov Mikhail M., Slavnova Elena N., Melnikova Nataliya V., Chernichenko Maria A., Sidorov Dmitry V., Kiseleva Marina V., Kaprin Andrey D., Alekseev Boris Y., Dmitriev Alexey A., Kudryavtseva Anna V.
- Журнал: BMC Genetics
- Том: 18
- Год издания: 2017
- Издательство: BioMed Central
- Местоположение издательства: London
- DOI: 10.1186/s12863-017-0581-8
- Аннотация: Background: Neuropilin and tolloid-like 2 (NETO2) is a single-pass transmembrane protein that has been shown primarily implicated in neuron-specific processes. Upregulation of NETO2 gene was also detected in several cancer types. In colorectal cancer (CRC), it was associated with tumor progression, invasion, and metastasis, and seems to be involved in epithelial-mesenchymal transition (EMT). However, the mechanism of NETO2 action is still poorly understood. Results: We have revealed significant increase in the expression of NETO2 gene and deregulation of eight EMT-related genes in CRC. Four of them were upregulated (TWIST1, SNAIL1, LEF1, and FOXA2); the mRNA levels of other genes (FOXA1, BMP2, BMP5, and SMAD7) were decreased. Expression of NETO2 gene was weakly correlated with that of genes involved in the EMT process. Conclusions: We found considerable NETO2 upregulation, but no significant correlation between the expression of NETO2 and EMT-related genes in CRC. Thus, NETO2 may be involved in CRC progression, but is not directly associated with EMT.
- Добавил в систему: Харитонов Сергей Леонидович