Аннотация:The paper gives a survey of the methods, used for preparation of multicomponent catalytical systems, that involve conventional chemical modification of polymers by biologically active compounds or copolymerization of the corresponding macromonomers with hydrophilic monomers. Using the enzyme-cofactor system and mixtures of enzymes (protease-heparin, protease-hydrocarbon radical, serum albumin-oxyreductase, etc.) as examples we show that the occurrence of consecutive catalytical reactions is possible only when the arrangement of the immobilized compounds in the bulk of the polymer or at its surface is favorable. Polymer modification using copolymerization is shown to be the procedure that best conforms to this requirement. The prospects of using multicomponent systems to control enzyme specificity, create blood compatible polymeric materials, and enhance the efficaciousness/efficiency of biospecific sorbents are demonstrated.