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Stabilization of Enzymes-Antioxidants by Complex and Conjugate Formation with Block Copolymers: Prospects for CNS Treatmentстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 февраля 2014 г.
- Авторы: Uglanova S.V.a, Popov M.V.b, Kurova V.S.a, Batrakova E.V.c, Manickam D.c., Kabanov A.V.c, Klyachko N.L.b
- Журнал: Moscow University Chemistry Bulletin
- Том: 65
- Номер: 3
- Год издания: 2010
- Издательство: Allerton Press Inc.
- Местоположение издательства: United States
- Первая страница: 190
- Последняя страница: 196
- DOI: 10.3103/S0027131410030168
- Аннотация: Nanosized particles with a radius of 16 В± 2 nm based on complexes and conjugates of highly active superoxide dismutase and catalase with polyelectrolyte block copolymer poly(ethyleneimine)-poly(ethylene glycol) and similar bienzyme systems were obtained. Mass spectrometry was used to confirm the crosslinking of enzyme and block copolymer molecules in the nanoparticles that were formed. A significant increase of SOD and catalase stability (up to four times) towards proteolytic degradation under chymotrypsin and trypsin action for 3 h at 37В°C was revealed when enzyme-containing nanoparticles were used for experiments. Antioxidant enzymes-containing polyelectrolyte nanoparticles seem to be promising for BBB penetration and CNS drug delivery. В© 2010 Allerton Press, Inc.
- Добавил в систему: Клячко Наталья Львовна