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SURFACE-MODIFIED NANODIAMONDS AS CARRIERS FOR 99mTcтезисы доклада
- Авторы: Garashchenko B.L., Garashchenko B.L., Yakovlev R.Y., Yakovlev R.Y., German K.E., German K.E., Myasoedov B.F., Myasoedov B.F.
- Сборник: Proceedings and selected lectures of the 10th International Symposium on Technetium and Rhenium – Science and Utilization, October 3-6, 2018 - Moscow – Russia
- Том: 10
- Тезисы
- Год издания: 2018
- Место издания: Publishing house Granica Moscow
- Первая страница: 472
- Последняя страница: 485
- Аннотация: One of the main requirements for novel radiopharmaceuticals (RPs) is swift (<15 min) targeted accumulation. This is necessary for the reduction of impact of radiation from the radionuclide on healthy tissues, what can be achieved by using lipophilic nanoparticles with high membrane permeability. The other general requirements to nanocarriers in RPs are biocompatibility, non-toxicity, selective accumulation in targeted organs, radiation resistance and a significant ability to retain radionuclides. One of the promising classes of nanoparticles capable of meeting all these requirements are modified nanodiamonds [1-2]. The possibility of covalent sewing of any organic compound on the surface of nanodiamonds may give an opportunity of modeling the degree of retention of the radionuclide and its biodistribution. In this work, to solve the problem of creating a nanodiamond-technetium conjugate, stable in a biological medium, the initial nanodiamonds of detonation synthesis were modified by organic compounds. Among these substances were derivatives of amino acids, EDTA and others. Data were obtained on the effect of pH on the labeling yield of the nanodiamond conjugate, as well as the concentration of the conjugate and the concentration of technetium. The kinetics of sorption and desorption of technetium has been studied within the limits of the time appropriate for the clinical synthesis. This work is supported by the Russian Science Foundation (project № 18-13-00413).
- Добавил в систему: Герман Константин Эдуардович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | elibrary_36671842_42873513_Garaschenko_nanodiamonds.pdf | 1,4 МБ | 29 января 2019 [Konstantin-German] |