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The influence of neonatal ketamine injection on pain sensitivity and audiogenic seizures in adult ratsстатья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.
- Авторы: Salonin D.V., Perepelkina O.V., Markina N.V., Gichenok I.A., Kuznetsova G.D., Poletaeva I.I.
- Журнал: I.P. Pavlov Journal of Higher Nervous Activity
- Том: 54
- Номер: 2
- Год издания: 2004
- Первая страница: 277
- Последняя страница: 282
- Аннотация: The remote effects of neonatal (on the 3d-to-9th postnatal days) ketamine injections (10 and 50 mg/kg in 20μl of distilled water, s.c.) were analyzed in adult Wistar, WAG/Rij, and KM (a strain with high audiogenic sensitivity) rats. Both ketamine and water injections increased pain sensitivity in adult rats. Neonatally injected water increased the mean score of seizures in Wistar and WAG/Rij, whereas ketamine water solution injected in the dose of 50 mg/kg did not change the seizure intensity (as compared to the intact control). Consequently, ketamine significantly reduced the mean score of the audiogenic seizure fit without change in its latency. In highly sensitive KM rats the neonatally injected ketamine (50 mg/kg) significantly shortened the mean latency of the fit onset, and fit stages developed faster. Thus, the neonatal ketamine injection increased the audiogenic seizure susceptibility of brain structures in KM rats. © 2004.
- Добавил в систему: Перепелкина Ольга Викторовна