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Title: Proton leakage across lipid bilayers: Oxygen atoms of phospholipid ester linkers align water molecules into transmembrane water wiresстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 июня 2019 г.
- Авторы: Bozdaganyan Marine E., Lokhmatikov Alexey V., Natalia Voskoboynikova, Cherepanov Dmitry A., Heinz-Juergen Steinhoff, Shaitan Konstantin V., Mulkidjanian Armen Y.
- Журнал: Biochimica et Biophysica Acta - Bioenergetics
- Том: 1860
- Номер: 6
- Год издания: 2019
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 439
- Последняя страница: 451
- DOI: 10.1016/j.bbabio.2019.03.001
- Аннотация: Up to half of the cellular energy gets lost owing to membrane proton leakage. The permeability of lipid bilayers to protons is by several orders of magnitude higher than to other cations, which implies efficient proton-specific passages. The nature of these passages remains obscure. By combining experimental measurements of proton flow across phosphatidylcholine vesicles, steered molecular dynamics (MD) simulations of phosphatidylcholine bilayers and kinetic modeling, we have analyzed whether protons could pass between opposite phospholipid molecules when they sporadically converge. The MD simulations showed that each time, when the phosphorus atoms of the two phosphatidylcholine molecules got closer than 1.6 nm, the eight oxygen atoms of their ester linkages could form a transmembrane ‘oxygen passage’ along which several water molecules aligned into a water wire. Proton permeability along such water wires would be limited by rearrangement of oxygen atoms, which could explain the experimentally shown independence of the proton permeability of pH, H2O/D2O substitution, and membrane dipole potential. We suggest that protons can cross lipid bilayers by moving along short, self-sustaining water wires supported by oxygen atoms of lipid ester linkages.
- Добавил в систему: Мулкиджанян Армен Яковлевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | статья и сопроводительные материалы | Bozdaganyan_BBA_2019_text_SI.pdf | 5,3 МБ | 8 апреля 2019 [Mulkidjanian] |
| 2. | supplement | Proton_dop_BBA.pdf | 10,6 МБ | 8 апреля 2019 [ShaitanKV] |