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Effect of 2,2 ’-dipyridyl on accumulation of protoporphyrin IX and its derivatives in yeast mitochondria and plasma membranesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 октября 2013 г.
- Авторы: Strakhovskaya M.G., Ivanova E.V., Kolesnikova O.A., Fraikin G.Y.
- Журнал: Biochemistry (Moscow)
- Том: 64
- Номер: 2
- Год издания: 1999
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 213
- Последняя страница: 216
- Аннотация: The iron chelator 2,2’-dipyridyl (0.2 mM) more than fourfold increased the concentration of protoporphyrin IX and also of its zinc-containing complex in mitochondria of the yeast Saccharomyces cerevisiae. Protoporphyrin IX and a chlorine derivative of protoporphyrin IX which fluoresces at 670-675 nm were found in isolated plasma membranes of the yeast grown in the presence of 0.2 mM 2,2’-dipyridyl. The accumulation of endogenous porphyrins resulted in intensification of lipid photoperoxidation in mitochondria and plasma membranes and in a dramatically increased sensitivity of the cells to visible light (400-600 nm). The relative contribution of photodestruction of subcellular structures to photoinduced cell inactivation is discussed.
- Добавил в систему: Страховская Марина Глебовна