Synthesis of d-(+)-camphor-based N-acylhydrazones and their antiviral activityстатья

Информация о цитировании статьи получена из Scopus, Web of Science
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Дата последнего поиска статьи во внешних источниках: 26 апреля 2019 г.

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[1] Synthesis of d-(+)-camphor-based n-acylhydrazones and their antiviral activity / K. S. Kovaleva, F. I. Zubkov, N. I. Bormotov et al. // MedChemComm. — 2018. — Vol. 9, no. 12. — P. 2072–2082. The design and synthesis of a series of novel D-(+)-camphor N-acylhydrazones exhibiting inhibitory activity against vaccinia and influenza viruses are presented. An easy pathway to camphor-based N-acylhydrazones containing in their structure aliphatic, aromatic, and heterocyclic pharmacophore scaffolds has been developed. The conformation and configuration of the synthesized hydrazones were thoroughly characterized by a complete set of spectral characterization techniques, including 2D NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. In vitro screening for activity against vaccinia virus (VV) and influenza H1N1 virus was carried out for the obtained compounds. It was revealed that the derived N-acylhydrazones exhibited significant antiviral activity with a selectivity index >280 against VV for the most promising compound. [ DOI ]

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