Аннотация:Human activities in the world cause discharge of chemical compounds in water. These pollutants persist in the environment and are lipophilic (deposit in multicellular organisms).They inhibit the growth and green algae photosynthetic activity, decrease the growth and fish breeding. Some organic compounds are deletered for man (adult infertility, growth reduction, infant intellectual skills attack). In Mali, the medicine used to fight against malaria, urban transportation and coming from solid waste incineration contributed to aquatic ecosystem degradation. Through food chain chemical compounds concentration increases (Duggan et al., 1966; Nash and Woolson, 1967; Orris P.L et al., 2000). A special consideration was given to pollutant accumulation by superior trophic level organisms as fishes. That study was based on the evaluation of chemical compounds in Niger river in Bamako fishes and the impact on environment. Key objectives are to determine chemical compounds concentration in tissues from Bamako river Niger fishes, determine lethal dosage of chemical products rats and mouse in vivo;