Neurodegenerative Changes in Rat Brain in Streptozotocin Model of Alzheimer’s Diseaseстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 июня 2019 г.
Аннотация:One of the most common models of sporadic form of Alzheimer's disease is
injection of streptozotocin into the lateral ventricles of rat brain. In 3 months
after this injection, an increase in the expression of astroglia in the corpus
callosum and a decrease in the thickness of the corpus callosum and intensity of
its staining with luxol fast blue were observed. This can reflect a decrease in
the content of myelinated fibers. In layer V of the sensorimotor cortex,
intensive degeneration of neurons was revealed. The lateral ventricles were
significantly enlarged and the expression of PSA-NCAM protein, a marker of
immature neurons, was reduced in subventricular zone, which can be associated
with disturbed neurogenesi.